SRC's  Dermal (DermWin) Program

This program estimates the dermal permeability coefficient (Kp) and the dermally absorbed dose per event (DAevent) of organic compounds from its chemical structure and SRC's LogKow (KowWin) program to estimate the octanol/water partition coefficient. The estimation methodology was taken from the EPA document Dermal Exposure Assessment: Principles and Applications (EPA/600/8-91-011B, January 1992). The program uses one general estimation equation and three specific class estimation equations to predict Kp. DAevent is predicted by two separate methods (an adapted equation of Fick's first law and another method; both of which are indicated in the EPA report) and requires (1) input of the duration of the event, and (2) concentration of the chemical in water (a default water solubility using the method in SRC's WsKow program is calculated for the user if no value is entered).

The newest version of Dermal runs under Windows (3.1, 95, 98, NT) making the estimation of dermal permiability coefficients more convenient and accurate. Methods for chemical structure input now support SMILES notations as well as chemical structures produced in popular chemical drawing programs. Enhanced features of the Windows version include batch-mode data entry and user functions.

Example Entry / Results Window (for Michler's Ketone)